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NAC: glutathione precursor, not a magic pill

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By NSW Editorial Team · Reviewed by the NSW Editorial Board · Updated

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Quick answer

N-acetylcysteine (NAC) is the acetylated form of the amino acid cysteine. It serves as a precursor to glutathione, the body's primary intracellular antioxidant. NAC has well-established clinical uses for acetaminophen overdose, mucolytic therapy, and contrast-induced nephropathy prevention. Recreational supplement use for general wellness has less robust evidence.

Mechanism

NAC donates cysteine to glutathione synthesis. It also has direct radical-scavenging activity.

Dosing

For supplement use: 600 to 1200 mg per day, divided. Higher doses (1800 to 2400 mg) are used clinically.

Citations

FAQ

Educational, not medical. These statements have not been evaluated by the Food and Drug Administration. This content is for educational purposes only and is not a substitute for medical advice from a qualified healthcare provider. Not intended to diagnose, treat, cure, or prevent any disease.