Published by Genomax LLC, Wyoming · How we fund testing · Editorial standards · Methodology

Lion's mane and BDNF: separating mechanism from marketing

Editorial disclosure. This site is operated by Genomax LLC, which also operates the GenoMAX² supplement brand. Outbound product links may earn a commission. No supplement-brand sponsorship influences our ratings. See Editorial Standards and How We Review.

By NSW Editorial Team · Reviewed by the NSW Editorial Board · Updated

Editorial disclosure: site operated by GenoMAX².

Quick answer

Hericium erinaceus (lion's mane) contains compounds called hericenones and erinacines that have been shown in cell culture and rodent models to increase nerve growth factor expression. Human clinical data is limited but suggestive. Typical supplement dose is 500 to 3000 mg of fruiting body extract per day. Effects, when present, develop over weeks not days.

Compound classes

What the evidence shows

In-vitro and rodent models show NGF upregulation. One 2019 RCT in adults reported improvement on cognitive function scales after 12 weeks at 1050 mg per day.

Citations

FAQ

Educational, not medical. These statements have not been evaluated by the Food and Drug Administration. This content is for educational purposes only and is not a substitute for medical advice from a qualified healthcare provider. Not intended to diagnose, treat, cure, or prevent any disease.